Pittsburgh Penguins center Sidney Crosby (87) scores past Tampa Bay Lightning goalie Andrei Vasilevskiy (88), of Russia, while sliding across the ice during the first period of an NHL hockey game Saturday, Dec. 10, 2016, in Tampa, Fla. (Chris O'Meara/AP)
Crosby opened the scoring 12:03 into the game, diving toward a loose puck and putting it past Vasilevskiy.
"The first goal he got, for me, personifies his compete level, his willingness to go to the battle area," Penguins coach Mike Sullivan said.
Crosby has a goal in three straight games and a seven-game point streak (six goals, 12 points).
Tampa Bay got a four-minute power play late in the first after Drouin was cut below the left eye from a high stick by Malkin. Drouin returned soon after and tied it at 1 from the left circle with 2:03 left.
Drouin put the Lightning up 3-1 midway through the second by lifting a backhander past Murray.
"I think we were in it physically and emotionally," Drouin said. "But you can't give that team too many chances."
Murray made a terrific glove save along the goal line in the third.
"I think I was pretty lucky," Murray said.
Game notes Pittsburgh has outscored opponents 39-17 in the third period. ... Malkin has a 13-game point streak against Tampa Bay (15 goals, 30 points). ... Lightning RW Ryan Callahan missed his sixth straight game. He has played in just 15 games since offseason hip surgery.
Penguins: Play Arizona on Monday night in the first of three straight games at home.
Lightning: Start a three-game trip Wednesday night at Calgary.